A1

From NeuronBankWiki

A1 is an interneuron in Pleurobranchaea

NeuronBank Accession ID: Ple0002601

Homologous to C2 in Tritonia

Contents 1 Anatomy 2 Electrophysiology 3 Synapses 3.1 Inputs 3.2 Outputs 4 Behavior 5 References

Anatomy

• Soma:
  • Coloration: White
  • Location: The larger, more anterolateral of the two white cells in the A cluster of the of the cerebral ganglion.
  • size: 50 -110 microns in animals 10 - 600 gm - slightly larger than nearby neurons
• Axon Projection: Contralateral through cerebral commissure, then through anterior cerebropedal connective to pedal ganglion, then through pedal commissure

Electrophysiology

• Resting Membrane Potential: -48.6 mV
• Spike Height: 70.3 mV

Synapses

Inputs

• Excited by sensory afferents - no indication of whether this is mono or polysynaptic
• Electrically coupled to A3 and inhibited by A3

Outputs

• Polysynaptic inhibition of Phasic Paracerebral Neuron (PC_p)

Behavior

• A1 is a member of the swim CPG circuit. It is rhythmically active during the swim motor pattern and can reset the motor pattern.
• A1 stimulation inhibits feeding.
• Stimulation of A1 in non-swimming whole-animal preparation has a biphasic effect:

1. The animal straightens like a dorsal flexion
2. The animal turns to the side contralateral to the A1 soma being stimulated.

References

• J. Jing and R. Gillette. Neuronal elements that mediate escape swimming and suppress feeding behavior in the predatory sea slug Pleurobranchaea. J.Neurophysiol. 74 (5):1900-1910, 1995.PMID:8592183
• J. Jing and R. Gillette. Central pattern generator for escape swimming in the notaspid sea slug Pleurobranchaea californica. J.Neurophysiol. 81 (2):654-667, 1999. PMID:10036268