CA3 pyramidal neuron
From NeuronBankWiki
CA3 pyramidal neuron is one of many neurons that are found within the body's nervous system.
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CA3 pyramidal neuron
The CA3 pyramidal neuron is located within the hippocampus of the brain’s temporal lobe. This neuron is regulated by various inhibitory neurons and is also used for the retention of information (memory). The CA3 region itself is located within the hippocampus. The specific location of this region is called Ammon's horn. The CA3 region receives information from the dentate gyrus neurons. An important axon linking this neuron to the CA1 pyramidal neuron is the Schaffer collateral. These axons are seen as important because they involved in memory formation.
Neuronal Type: Projection neuron
Anatomy
- The main cell body is within Ammon's horn of the hypothalamus
- There are usually multiple branching dentrites to take in information and a single axon to send it away.
- There are generally 100,000 of these neurons in a normal human brain
Molecular profile
- Neurotransmitter: Glutamate (common neurotransmitter in mammals)
Physiology
Synaptic Inputs
Dentate basket cells are one of the types of cells that the CA3 pyramidal neurons receive information from.
Synaptic Outputs
The CA1 pyramidal neuron is a neuron that receives information from the CA3 pyramidal neuron.
Spiking properties
The CA3 neuron has a very cool type of spiking know as bursting. Here multiple action potentials take place and then hit a refractory (period in which an action potential cannot be fired) period.
Behavior
The CA3 neuron appears to work with the CA1 pyramidal neuron and a few other types of neurons in the retention of information. Depending on how many times the information is either seen and/or recalled the more likely it will stored in the long term compartment vs. the short term
References
Sun HY, Lyons SA, Dobrunz LE.(2005) Mechanisms of target-cell specific short-term plasticity at Schaffer collateral synapses onto interneurones versus pyramidal cells in juvenile rats, The Journal of Physiology, vol: 568 pages: 815–840. 2005 August 18.
Speed HE, Dobrunz LE. (2008) Developmental Decrease in Short-Term Facilitation at Schaffer Collateral Synapses in Hippocampus Is mGluR1 Sensitive, Journal of Neurophysiology, vol:99, pages: 799-813. November 21, 2007
Bear, Mark F., Barry W. Connors, and Micheal A Paradiso. Neuroscience: exploring the brain. 3rd. Lippincott Williams & Wilkins, 2007.
Extra inferences can be seen here: http://senselab.med.yale.edu/modeldb/ShowModel.asp?model=118098
