CN Bushy Cells
From NeuronBankWiki
CN Bushy Cells is a Ventral Cochlear Nucleas neuron.
Contents |
NS neuron
CN bushy cells are cochlear nucleus neurons that are located close to the entrance of the auditory nerve. There are two types of bushy cells a spherical and a globular cell. These cells derive their names from the shape of their cell bodies or somata. The branched out "tree-like" geometry and pattern of these cells gives bushy cells their names. Bushy cells have one of the most secure synapses in the brain because they have the ability to contact principal cells of the medial nucleus of the trapezoid body with the large calyx of Held. The excitatory and inhibitory inputs from other neuronsn are GABA and Glutamate. Receptors for GABA and Calcium can be found in the soma of the cells also.
Neuronal Type: Sensory Neuron
Anatomy
- Where is the Cell body located?
The cell body or the soma of bushy cells is located in the core or central region of the ventral cochlear nucleus.
- What is the axon projection pattern?
CN bushy cells have axon projections called dendrites that form tree like structures. These branches of the dendrites can consist of one or two dendritic branches that form complex tree like branch structures. These branches can then form "clusters" around the somata of surrounding cells.
- How many neurons of this type are there in the nervous system?
Information was not present in literature.
Molecular profile
- Neurotransmitter: current literautre suggest electrical signals
- Unique molecular markers:
Physiology
Synaptic Connections
Synaptic connections such as sarcoplasmic junctions and gap junctions suggest that CN bushy cells are electrically coupled together. Electrical coupling of the cells allows for ions to flow freely between different cells. Spherical bushy cells have regions call endbulbs of Held which are terminal sites of the nerve where large synaptic complexes can form which will guarantee transmission of high quality information throught the cell and to connecting cells. Synaptic connections of these cells can have as many as four main subtypes of endings which will determine the size of the endings making the connection and the shape of the vessicles it uses.
Synaptic Inputs
Dendrites are the main cell surface site of synaptic inputs because they have the ability to integrate the excitatory and inhibitory information received by other neurons. These inputs are of cochelar and non cochlear origin.Dendrites also have receptors that recognize glutamate vesicles from synapsing auditory neurons. The type of inputs into dendritic bushy cells determines the shape of synaptic vessicles and the symmetry of the synaptic conncetion. Excitatory endings make assymetric synaptic conncetions with round or circular vessicles while inhibitory endings make symmetrical connections with flattened vessicles. Excitatory inputs for bushy cells is Glutamate while the inhibitory inputs for these cells is GABA.
Synaptic Outputs
Electrical coupling of CN bushy cells suggest that output from these cells may be that of an electrical source.
Spiking properties
Spiking properties are affected by the moderate to strong depolarization of the cell membrane due to calcium signaling.
Behavior
Neuronal excitability can be adjusted by the the activity of the spherical bushy cells (SBCs). This activity of the SBCs is possibly motivated by the endbulbs of Held which can experience a corelease of ATP and glutamate during excitatory synaptic inputs.
References
- Ivan Milenkovic,Ilka Rinke,Mirko Witte,Beatric Dietz,Rudolf Rubsamen (2009) P2 receptor mediated signaling in spherical bushy cells of the mammalian cochlear nucleus, Press.J Neurophysiology, doi:10.1152/jn.00186.2009
- Ricardo Gomez-Nieto,Maria E. Rubio (2009) The Bushy Cell in the Rat Ventral Cochlear Nucleus, The Journal of Comparative Neurobiology, 516: 241-263.
- W.S. Rhode, (2008) Response Patterns to Sound Associated with Labled Globular/Bushy Cells in Cats, Neuroscience, 154: 87-98.
