Double bouquet cell
A double bouquet cell (DBC) is an GABAergic interneuron found in several different cortical areas in mammals.
Double bouquet cells get their name from their bitufted dendritic morphology. They are very numerous in the visual cortex and are believed to exert influence in the vertical dimension. These neurons have sparked particular interest in analyzing cortical circuits. There are a large number of these interneurons that are readily distributed in the cortical regions, but there are variations in morphology and density among different mammals.
The cell body of DBCs are relatively small, oval in shape, and vertically oriented. The axons of DBC are readily recognized due to their unique pattern of long tightly interwoven vertical bundles that resemble a horsetail. The organization of DBCs within the cerebral cortex shows a microcolumnar structure which is present through several layers of the cortex.
DBCs are GABAergic interneurons that can be recognized using immunocytochemistry staining for calbindin D-28k as well as calretinin. They are also immunoreactive to vasoactive intestinal polypeptide (VIP). (Please provide a reference for this --Pkatz 22:55, 28 August 2008 (EDT))
DBCs have post synaptic interactions with the shafts of dendrites as well as dendritic spines. These synapses are symmetrical. (I don't understand these statements --Pkatz 22:55, 28 August 2008 (EDT))
There have been several experiments to determine the spiking patterns of DBCs. They have been classified under several spiking patterns including intermediate spiking, fast spiking, and burst spiking.
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