M5
From NeuronBankWiki
M5 is a neuron in Caenorhabditis elegans.
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M5 neuron
The M5 neuron is a pharyngeal motor neuron. It is the only neuron in which the synapses to the terminal bulb muscle is visible. To the left of its cell body is a subdorsal posterior terminal bulb, at which they synapse on the terminal bulb muscles pm6 and pm7.
Neuronal Type: Pharyngeal Motor Neuron
Anatomy
• The M5 pharyngeal motor neuron is located in the pharynx posterior bulb. • It sends one dorsal and one ventral process a process. The dorsal process results in a semicircle lagging behind the pm7. They both then cross on the ventral side and reach the terminal bulb commissural as a result from running along the side of the ventral marginal cell. These processes are continued, passing under the cell bodies of other motor neurons such as M2. They eventually meet in gap junctions located on the dorsal side of the terminal bulb commissural. Along the pathway in the process, they also send short, posterior branches. These branches can run on either side of the subdorsal marginal cells. • There are 7 pharyngeal motor neurons in the nervous system of Caenorhabditis elegans - M1 - M2L - M2R - M3L - M3R - M4 - M5
Molecular profile
- Neurotransmitter: Possibly Acetycholine
- Unique molecular markers:
o Expresses FMRFamide-like peptide, FLP-1 precursor o Receptor Expression: Expresses glutamate receptor subunit GLR-8
Physiology
o M5 is a pharyngeal motor neuron with unknown function Synaptic Connections - Synaptic Inputs & Synaptic Outputs M5 has a branch in each subventral cord and brings its synaptic outputs onto muscles. Each branch travels to the dorsal side to synapse onto the dorsal muscle sector. Therefore, having a dorsal sector receive input via synapse from both branches of dorsal cells, or paired subventral cells, can innervate the three muscle sectors of the pharynx. - Spiking properties No spiking properties of M5 pharyngeal motor neurons have been detected.
Behavior
M5 causes a behavioral effect with MC motor neurons. M5 neuron pumps become slightly briefer when killed simultaneously with MC motor neurons as opposed to when MC motor neurons are killed alone.
References
1. Avery, Leon. (1996) Pharyngeal Motor Neuron M5, http://elegans.swmed.edu/htbin/imageidx/I6_M5c?159,102 2. Caenorhabditis elegans. WORMATLAS. (2009) http://www.wormatlas.org/neurons/Individual%20Neurons/M5frameset.html.
