Metacerebral cell

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The Metacerebral Cell (MCC) is a giant serotonergic neuron in the Aplysia californica cerebral ganglia of the mollusc.

Neurotransmitter: 5-HT

Figure 1. Dorsal view of the cerebral ganglion of Aplysia californica, including the location of the serotonergic MCC. Modified from Moroz et al 2006.


1. Katzoff A, Ben-Gedalya T, Hurwitz I, Miller N, Susswein YZ, Susswein AJ, (2006)Nitric oxide signals that aplysia have attempted to eat, a necessary component of memory formation after learning that food is inedible. J Neurophysiol. 96:1247-57

2. Jacklet JW, Grizzaffi J, Tieman DG (2006) Serotonin and cAMP induce excitatory modulation of a serotonergic neuron. J Neurobiol. 66:499-510

3. Jacklet JW, Grizzaffi J, Tieman D. (2004) Serotonin, nitric oxide and histamine enhance the excitability of neuron MCC by diverse mechanisms. Acta Biol Hung. 55:201-10