Raphe Nuclei

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This page will be update by the 27th of Auj. Ninad Mehta


Introduction

During the mid-nineteen century it was observed that the serum that was left after the clotting of the blood could constrict vascular smooth muscle so as to increase the vascular tone. It was later discovered that blood platelets were a source of this substance. Rapport and this collaborators[1] later isolated this compound and named it serotonin(5-hydrocytryptamine). Since the structure of 5-HT is hydrophilic and this would imply that I would not be able to pass through the blood-brain barrier and thus the presence of 5-HT in the blood suggested that it was produced in the brain. In 1964, Dahlstrom and Fuxe using the method of histoflurescence found that the majority of serotonergic soma was found in the midline of the brainstem. This locus had been designated as the raphe nuclei[2]. One fact that must be kept in mind is that not all the neurons in the raphe nuclei are serotonergic.


Schematic drawing depicting the location of the serotonergic cell body groups in a sagittal section of the rat central nervous system and their major projections. OT, olfactory tuberculum; Sept, septum; C. Put, nucleus caudate-putamen; G. Pal, globus pallidus; T, thalamus; H, habenula; S. Nigra, substantia nigra.[1] http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=bnchm.figgrp.950

Anatomy

Traditional Dahlstrom and Fuxe described nine group of serotonin-containing cell bodies and they were designated B1 to B9. The figure shows the nine cell bodies and the region of the brain the invigilate.

Molecular profile

  • Neurotransmitter: ____________
  • Unique molecular markers: ______________

Physiology

Synaptic Connections

Synaptic Inputs

Synaptic Outputs

Spiking properties

Behavior

References

  1. Author1 FM,Author2 FM (year) Title, Journal, vol: pages. PMID.
  2. Author1 FM,Author2 FM (year) Title, Journal, vol: pages. PMID.


Additional information

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