Type I spiral ganglion neuron

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Anatomy

The cell bodies of type I spiral ganglion neurons (SGNs) is located within the spiral ganglion in the cochlea. A single dendrite projects to the sensory epithelium of the cochlea and forms a synapse with a single presynaptic ribbon of an Inner Hair Cell (IHC). A single Axon projects to the Cochlear Nuclei via cranial nerve VIII (vestibulocochlear), within the cochlear nuclei, the axon bifurcates and sends projections to the ventral and dorsal cochlear nuclei.


Connections

Input: Inner Hair Cells (Glutamate - Excitatory), Lateral Olivocochlear Neurons (ACh, GABA, CGRP, dopamine, serotonin - Inhibitory).

Output: Cochlear Root Neurons and Cochlear Nuclei (Glutamate - Excitatory).


Spiking Properties

Type I SGNs display "spontaneous" spiking activity at rates of 0.1-100Hz, driven by spontaneous glutamate release at the IHC ribbon synapse. Excitation and Inhibition of IHCs increases and decreases the spike rate respectively.